Not medical advice. Semax is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
Semax is listed in our catalogue under “Cognitive / Neuro.” In scientific publications it is discussed in technical language; this page translates the general themes into everyday wording while staying faithful to research-only framing.
One-paragraph overview from our research datasheet — still scientific, but faster to read than the full mechanism list below.
Semax is a synthetic ACTH(4-10) heptapeptide nootropic that upregulates BDNF/TrkB signaling and modulates dopaminergic and serotonergic neurotransmission.
Peer-reviewed literature typically discusses Semax in specific experimental settings. The points below reflect how the scientific community frames this compound—not as health claims, but as the research questions being asked.
Research vs. personal use: Literature describes experiments in controlled lab and animal models. This is distinct from any real-world use; our products are for laboratory research only.
Cognitive-related peptides are explored for stress-response pathways, neuronal signalling, and behaviour in animal models -not as treatments for human brain conditions.
Our datasheet lists mechanistic themes observed in preclinical work. These are research endpoints, not health claims. They help scientists understand and compare pathways.
Storage requirements: Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation. · Learn best practices in our detailed storage guide.
Research dosing context: Literature typically discusses 200–600 μg intranasal; 100–300 μg subcutaneous · Once daily intranasal (0.1% solution, 2–3 drops per nostril) · Plasma half-life 3–5 minutes, but functional biological duration extends to 20–24 hours due to downstream BDNF/TrkB signaling cascades. Intranasal administration delivers 0.093% of total dose to rat brain within 2 minutes, of which 80% is intact Semax. Pro-Gly-Pro tripeptide is the primary metabolite. Poor oral bioavailability necessitates intranasal or parenteral routes. Russian clinical doses: 0.015–0.050 mg/kg intranasally.
Preparation steps: Follow our detailed reconstitution guide, use the calculator tool for volume confirmation, and always verify purity with the COA reading guide.
Intranasal delivery takes advantage of the olfactory nerve pathway to bypass the blood-brain barrier, delivering peptide directly to brain tissue. For a peptide with a 3-5 minute plasma half-life that needs to act in the brain, intranasal is much more efficient than systemic injection - you get peptide where you need it without fighting BBB exclusion.
No - the ACTH(4-10) fragment carries the neurotropic activity of ACTH but lacks the adrenal-stimulating portion of the full hormone (residues 1-13 are required for melanocortin receptor activation at adrenal cortex). So Semax is neurotrophic without being a cortisol stimulus, which was a deliberate design choice.
Both are Russian heptapeptides with Pro-Gly-Pro tails and intranasal delivery, but they come from different parent molecules. Semax is based on ACTH(4-10) and emphasises cognitive enhancement and neuroprotection; Selank is based on the immune peptide tuftsin and emphasises anxiolysis. They are sometimes used together in research protocols.
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The Pro-Gly-Pro tail makes Semax noticeably more stable than ACTH(4-10) alone, but standard peptide handling still applies.
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.
Other compounds researchers often read about alongside Semax.
Primary literature and registries for Semax, plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
Access concentration, batch info, variants, and current pricing on our shop.
Also known as: Semax, ACTH(4-10)-Pro-Gly-Pro, Semax Heptapeptide, MEHFPGP, ACTH 4-10 Analogue, Semax Acetate, N-Acetyl Semax, Семакс