Not medical advice. MGF is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
MGF is listed in our catalogue under “Muscle / Performance.” In scientific publications it is discussed in technical language; this page translates the general themes into everyday wording while staying faithful to research-only framing.
One-paragraph overview from our research datasheet — still scientific, but faster to read than the full mechanism list below.
MGF (Mechano Growth Factor) 24-amino-acid IGF-1Ec C-terminal E-domain peptide activates satellite cells via non-IGF-1R-mediated nuclear intracrine signaling.
Peer-reviewed literature typically discusses MGF in specific experimental settings. The points below reflect how the scientific community frames this compound—not as health claims, but as the research questions being asked.
Research vs. personal use: Literature describes experiments in controlled lab and animal models. This is distinct from any real-world use; our products are for laboratory research only.
Here the literature centres on muscle repair, growth-factor signalling, and how tissues respond after overload or injury in preclinical work.
Our datasheet lists mechanistic themes observed in preclinical work. These are research endpoints, not health claims. They help scientists understand and compare pathways.
Storage requirements: Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation. · Learn best practices in our detailed storage guide.
Research dosing context: Literature typically discusses 200-400 μg per injection site · Immediately post-exercise, bilaterally into trained muscle groups; 2-3 times weekly · Unmodified MGF t½ ~5-7 min, extremely rapid clearance necessitates site-specific intramuscular injection. MW 2848.09 Da (24 aa). Acts in autocrine/paracrine fashion at very low concentrations. Sequence highly conserved across mammalian species (25 aa in most mammals, 24 aa in humans). WADA-prohibited substance. Consider PEG-MGF for systemic applications requiring extended half-life.
Preparation steps: Follow our detailed reconstitution guide, use the calculator tool for volume confirmation, and always verify purity with the COA reading guide.
Both come from the same gene, but through different splicing. Mature IGF-1 acts through the IGF-1 receptor to drive protein synthesis and terminal differentiation. MGF's unique C-terminal E-domain acts through a non-IGF-1R nuclear intracrine mechanism and specifically activates satellite stem cells. They are temporally and functionally sequential steps in muscle repair rather than redundant signals.
Because the native peptide has a 5-7 minute half-life. If you inject it subcutaneously, it is cleared long before it can reach distal muscle groups. Site-specific intramuscular injection into the target muscle is the only way to get meaningful local concentrations with native MGF. For systemic protocols, PEG-MGF solves this with a PEG-based half-life extension.
Immediately post-exercise, bilaterally into the muscle groups that were trained. The timing mimics the body's endogenous MGF response, which appears in the acute phase after mechanical loading and then tapers off within a few minutes.
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. MGF is not the most stable peptide on the market - use reconstituted material promptly within the normal handling window.
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.
Primary literature and registries for MGF, plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
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Also known as: MGF, Mechano Growth Factor, IGF-1Ec, IGF-1Ec Splice Variant, MGF C-Terminal Peptide, MGF-24aa-E, Satellite Cell Activator